Identifying and definitional attributes | |
Metadata item type: | Data Element |
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Short name: | Human epidermal growth factor receptor-2 test result |
Synonymous names: | HER2 test result |
METEOR identifier: | 370572 |
Registration status: | Health, Standard 06/03/2009 |
Definition: | The result of a person's human epidermal growth factor receptor-2 (HER2) test, as represented by a code. |
Data Element Concept: | Person with cancer—human epidermal growth factor receptor-2 test result |
Value Domain: | Human epidermal growth factor receptor-2 (HER2) test result code N |
Data element attributes | |
Collection and usage attributes | |
Collection methods: | For cancer registries, collection of this data item should only be from notification and pathology reports relating to initial diagnosis and not for recurrent or subsequent metastatic disease. Where different values are available from multiple specimens, the appropriate values to enter are selected according to the following hierarchy of rules: When multiple HER2 values are available, the value established by the most accurate test is used as per the hierarchy: FISH > CISH/SISH > IHC. (See Person with cancer—HER2 test type, code N) If the HER2 values differ on multiple pathology reports for the same tumour, use the value from the larger specimen.For multifocal tumours, use the HER2 value from the largest focus or from a metastatic deposit; e.g. Lymph node metastasis. A smaller focus that is HER2 positive may in fact be the source of a metastasis and in this setting the patient would derive benefit from the therapy offered as a result of HER2 positive status. |
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Comments: | Human epidermal growth factor receptor-2 (HER2) promotes the growth of cancer cells. HER2 is also known as c-erB-2 and Her2/neu. Tumours that are HER2-positive tend to grow more quickly than other types of cancer. HER2 status is an important prognostic marker and predicts the response to several therapies. |
Source and reference attributes | |
Origin: | National Breast and Ovarian Cancer Centre (NBOCC) Australasian Association of Cancer Registries (AACR) Australian Institute of Health and Welfare (AIHW) |
Reference documents: | National Breast and Ovarian Cancer Centre and Australian Cancer Network. The Pathology reporting of breast cancer. A guide for pathologists, surgeons, radiologists and oncologists (3rd edition). National Breast and Ovarian Cancer Centre, Surry Hills, NSW, 2008. |
Relational attributes | |
Implementation in Data Set Specifications: | Breast cancer (Cancer registries) DSS Health, Superseded 01/09/2012 Breast cancer (cancer registries) NBPDS Health, Standard 01/09/2012 |