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Person with cancer—lung cancer molecular pathology test results, code N[N]

Identifying and definitional attributes

Metadata item type:Help on this termData Element
Short name:Help on this termMolecular test results (lung cancer)
Synonymous names:Help on this termMolecular pathology results
METeOR identifier:Help on this term434682
Registration status:Help on this termHealth, Standard 08/05/2014
Definition:Help on this termThe results of a molecular pathology test for genetic and molecular abnormalities in a person with cancer, as represented by a code.
Data Element Concept:Person with cancer—molecular pathology test results

Value domain attributes

Representational attributes

Representation class:Help on this termCode
Data type:Help on this termNumber
Format:Help on this termN[N]
Maximum character length:Help on this term2
Permissible values:Help on this term
ValueMeaning
1APC - adenomatous polyposis coli
2ATM - ataxia telangiectasia mutated
3EGFR - epidermal growth factor receptor
4ERBB4 - v-erb-a erythroblastic leukaemia viral oncogene homolog 4
5ERCC1 - excision repair cross-complementing rodent repair deficiency, complementation group 1
6KDR - kinase insert domain receptor
7KRAS - v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
8NF1 - neurofibromin 1
9PTEN - phosphatase and tensin homolog
10RB1 - retinoblastoma 1
11RRM1 - ribonucleotide reductase M1
12STK11 - serine/threonine kinase 11
13TYMS - thymidylate synthetase
14P53 - tumour protein p53
15ERBB2 - v-erb-a erythroblastic leukaemia viral oncogene homolog 2
16EML4-ALK - echinoderm microtubule-associated protein-like 4 – anaplastic lymphoma kinase
17B-RAF - v-Raf murine sarcoma viral oncogene homolog B1
18ROS - C-Ros Oncogene 1, Receptor Tyrosine Kinase
19MET - Met Proto-Oncogene (Hepatocyte Growth Factor Receptor)
88Other
Supplementary values:Help on this term
97Not applicable-no abnormalities detected
98Unknown whether abnormalities detected
99Abnormalities detected but type not stated/inadequately described

Collection and usage attributes

Guide for use:Help on this term

Each code represents a HUGO Gene Nomenclature Committee (HGNC) assigned unique gene symbol. The full name, location and additional information about each gene can be obtained from their online database at www.genenames.org.

Record the code for each genetic or molecular abnormality detected.

Molecular pathology testing is usually performed for non-small cell lung cancer (NSCLC) and when the result may influence treatment.

Source and reference attributes

Submitting organisation:Help on this termCancer Australia
Reference documents:Help on this term

Harris TJR & McCormick F 2010. The molecular pathology of cancer. Nat. Rev. Clin. Oncol. 7:251-265

Royal College of Pathologists of Australasia 2010. Lung cancer structured reporting protocol. 1st Edition (Version 1.0). Surry Hills, NSW: Royal College of Pathologists of Australasia

HGNC Database, HUGO Gene Nomenclature Committee (HGNC), EMBL Outstation - Hinxton, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK. Viewed 21 June 2011, http://www.genenames.org

Data element attributes

Collection and usage attributes

Guide for use:Help on this term

Record the results of a molecular pathology test for genetic and molecular abnormalities in a person with cancer.

This item should be completed when the data element Molecular pathology indicator is coded as 1, denoting that molecular testing has been performed.

Molecular testing is usually performed when the result may influence treatment. For example, somatic mutations in the EGFR gene are associated with favourable outcomes from treatment with gefitinib.
Collection methods:Help on this termThis information should be sought from the patient's pathology report.
Comments:Help on this termThe presence of genetic or molecular abnormalities may be of clinical significance and influence treatment decisions.

Source and reference attributes

Submitting organisation:Help on this termCancer Australia
Reference documents:Help on this term

Harris TJR & McCormick F 2010. The molecular pathology of cancer. Nat. Rev. Clin. Oncol. 7:251-265

Relational attributes

Related metadata references:Help on this term

See also Person with cancer—molecular pathology indicator, yes/no/unknown code N Health, Standard 08/05/2014

See also Person with cancer—molecular pathology test date, DDMMYYYY Health, Standard 08/05/2014

See also Person with cancer—molecular pathology test results, (other) code X[X(19)] Health, Standard 08/05/2014

Implementation in Data Set Specifications:Help on this term
All attributes +

Lung cancer (clinical) DSS Health, Superseded 14/05/2015

DSS specific attributes +

Lung cancer (clinical) NBPDS Health, Standard 14/05/2015

DSS specific attributes +
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