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Lung cancer immunohistochemistry type code N[N]

Identifying and definitional attributes

Metadata item type:Help on this termValue Domain
METeOR identifier:Help on this term433010
Registration status:Help on this termHealth, Standard 08/05/2014
Definition:Help on this termA code set representing immunohistochemical stains used to assist in the diagnosis of lung cancer.

Representational attributes

Representation class:Help on this termCode
Data type:Help on this termNumber
Format:Help on this termN[N]
Maximum character length:Help on this term2
Permissible values:Help on this term
ValueMeaning
1Thyroid transcription factor-1 (TTF-1)
2Cytokeratin 5 (CK5)
3Cytokeratin 6 (CK6)
4Cytokeratin 7 (CK7)
5Cytokeratin 20 (CK20)
6p53-related transcription factor p63 (p63)
7Napsin
88Other
Supplementary values:Help on this term
97Not applicable-immunohistochemical staining not performed
98Unknown if imunohistochemistry performed
99Immunohistochemistry performed but stains not stated/inadequately described

Collection and usage attributes

Guide for use:Help on this termRecord the code for each immunohistochemical profile obtained to assist in the diagnosis of lung cancer.
Comments:Help on this term

Thyroid transcription factor-1 and cytokeratin 7 and 20 can be useful, in conjunction with tumour morphology and clinical and radiological findings, to help to distinguish between primary and metastatic lung adenocarcinomas.

Cytokeratin 5/6 and p63 immunostaining is used by some pathologists to help to determine whether a tumour is a squamous or non-squamous type.

The majority (about 75%) of primary lung adenocarcinomas are CK7 positive, CK20 negative and TTF-1 positive and Napsin stains are positive in approximately 80% of of primary lung adenocarcinomas.

Source and reference attributes

Submitting organisation:Help on this termCancer Australia
Reference documents:Help on this termRoyal College of Pathologists of Australasia 2010. Lung cancer structured reporting protocol. 1st Edition (Version 1.0). Surry Hills, NSW: Royal College of Pathologists of Australasia

Relational attributes

Data elements implementing this value domain:Help on this term

Person with cancer—lung cancer immunohistochemistry type, code N[N] Health, Standard 08/05/2014

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