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Person—low-density lipoprotein cholesterol level (calculated), total millimoles per litre N[N].N

Identifying and definitional attributes

Metadata item type:Help on this termData Element
Short name:Help on this termCholesterol—LDL (calculated)
METeOR identifier:Help on this term270402
Registration status:Help on this termHealth, Superseded 01/10/2008
Definition:Help on this termA person's calculated low-density lipoprotein cholesterol (LDL-C).
Data Element Concept:Person—low-density lipoprotein cholesterol level

Value domain attributes

Representational attributes

Representation class:Help on this termTotal
Data type:Help on this termNumber
Format:Help on this termN[N].N
Maximum character length:Help on this term3
Supplementary values:Help on this term
ValueMeaning
99.9Not stated/inadequately described
Unit of measure:Help on this termMillimole per litre (mmol/L)

Data element attributes

Collection and usage attributes

Guide for use:Help on this term

Formula:

LDL-C = (plasma total cholesterol) - (high density lipoprotein cholesterol) - (fasting plasma triglyceride divided by 2.2).

Collection methods:Help on this term

The LDL-C is usually calculated from the Friedwald Equation (Friedwald et al. 1972), which depends on knowing the blood levels of the total cholesterol and HDL-C and the fasting level of the triglyceride.

Note that the Friedwald equation becomes unreliable when the plasma triglyceride exceeds 4.5 mmol/L.

Note also that while cholesterol levels are reliable for the first 24 hours after the onset of acute coronary syndromes, they may be unreliable for the subsequent 6 weeks after an event.

  • Measurement of lipid levels should be carried out by laboratories, or practices, which have been accredited to perform these tests by the National Association of Testing Authorities.
  • To be collected as a single venous blood sample, preferably following a 12-hour fast where only water and medications have been consumed.
Comments:Help on this term

High blood cholesterol is a key factor in heart, stroke and vascular disease, especially coronary heart disease (CHD).

Poor nutrition can be a contributing factor to heart, stroke and vascular disease as a population's level of saturated fat intake is the prime determinant of its level of blood cholesterol.

The majority of the cholesterol in plasma is transported as a component of LDL-C. Thus, the evidence linking CHD to plasma total cholesterol and LDL-C is essentially the same.

Source and reference attributes

Submitting organisation:Help on this termCardiovascular Data Working Group
Origin:Help on this termNational Heart Foundation of Australia and the Cardiac Society of Australia and New Zealand, Lipid Management Guidelines - 2001, MJA 2001; 175: S57-S88.

Relational attributes

Related metadata references:Help on this term

Supersedes Cholesterol-LDL calculated, version 1, Derived DE, NHDD, NHIMG, Superseded 01/03/2005 .pdf (19.7 KB)

Is formed using Health service event—fasting indicator, code N Health, Standard 21/09/2005

Is formed using Person—cholesterol level (measured), total millimoles per litre N[N].N Health, Superseded 01/10/2008

Is formed using Person—high-density lipoprotein cholesterol level (measured), total millimoles per litre [N].NN Health, Standard 01/03/2005

Has been superseded by Person—low-density lipoprotein cholesterol level (calculated), total millimoles per litre N[N].N Health, Standard 01/10/2008

Is formed using Person—triglyceride level (measured), total millimoles per litre N[N].N Health, Superseded 01/10/2008

Implementation in Data Set Specifications:Help on this term
All attributes +

Acute coronary syndrome (clinical) DSS Health, Superseded 01/10/2008

Acute coronary syndrome (clinical) DSS Health, Superseded 07/12/2005

Cardiovascular disease (clinical) DSS Health, Superseded 15/02/2006

DSS specific attributes +

Cardiovascular disease (clinical) DSS Health, Superseded 04/07/2007

DSS specific attributes +

Cardiovascular disease (clinical) DSS Health, Superseded 22/12/2009

DSS specific attributes +
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