Person—low-density lipoprotein cholesterol level (calculated), total millimoles per litre N[N].N
Data Element Attributes
Identifying and definitional attributes | |
Metadata item type:![]() | Data Element |
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Short name:![]() | Cholesterol—LDL (calculated) |
METEOR identifier:![]() | 359262 |
Registration status:![]() | Health, Standard 01/10/2008 |
Definition:![]() | A person's calculated low-density lipoprotein cholesterol (LDL-C) in millimoles per litre. |
Data Element Concept:![]() | Person—low-density lipoprotein cholesterol level |
Value Domain:![]() | Millimoles per litre N[N].N |
Data element attributes | |
Collection and usage attributes | |
Guide for use:![]() | Formula: LDL-C = (plasma total cholesterol) - (high density lipoprotein cholesterol) - (fasting plasma triglyceride divided by 2.2). |
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Collection methods:![]() | The LDL-C is usually calculated from the Friedwald Equation (Friedwald et al. 1972), which depends on knowing the blood levels of the total cholesterol and HDL-C and the fasting level of the triglyceride. Note that the Friedwald equation becomes unreliable when the plasma triglyceride exceeds 4.5 mmol/L. Note also that while cholesterol levels are reliable for the first 24 hours after the onset of acute coronary syndromes, they may be unreliable for the subsequent 8 weeks after an event.
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Comments:![]() | High blood cholesterol is a key factor in heart, stroke and vascular disease, especially coronary heart disease (CHD). Poor nutrition can be a contributing factor to heart, stroke and vascular disease as a population's level of saturated fat intake is the prime determinant of its level of blood cholesterol. The majority of the cholesterol in plasma is transported as a component of LDL-C. Recent trials support a target LDL-C of <2.0 mmol/L for high risk patients with existing coronary heart disease. |
Source and reference attributes | |
Submitting organisation:![]() | Cardiovascular Data Working Group |
Origin:![]() | National Heart Foundation of Australia and the Cardiac Society of Australia and New Zealand, Lipid Management Guidelines - 2001, MJA 2001; 175: S57-S88. National Heart Foundation of Australia and the Cardiac Society of Australia and New Zealand, Position Statement on Lipid Management - 2005, Heart, Lung and Circulation 2005; 14: 275-291. |
Relational attributes | |
Related metadata references:![]() | Supersedes Person—low-density lipoprotein cholesterol level (calculated), total millimoles per litre N[N].N Health, Superseded 01/10/2008 Is formed using Health service event—fasting indicator, code N Health, Standard 21/09/2005 Is formed using Person—cholesterol level (measured), total millimoles per litre N[N].N Health, Superseded 01/10/2008 Is formed using Person—high-density lipoprotein cholesterol level (measured), total millimoles per litre [N].NN Health, Standard 01/03/2005 Is formed using Person—triglyceride level (measured), total millimoles per litre N[N].N Health, Superseded 01/10/2008 |
Implementation in Data Set Specifications:![]() | Acute coronary syndrome (clinical) DSS Health, Superseded 01/09/2012 Acute coronary syndrome (clinical) DSS Health, Superseded 02/05/2013 Acute coronary syndrome (clinical) NBPDS 2013- Health, Standard 02/05/2013 Implementation start date: 01/07/2013 Cardiovascular disease (clinical) DSS Health, Superseded 01/09/2012 DSS specific information: Many studies have demonstrated the significance of blood cholesterol components as risk factors for heart, stroke and vascular disease. Scientific studies have shown a continuous relationship between lipid levels and Coronary Heart Disease (CHD) and overwhelming evidence that lipid lowering interventions reduces CHD progression, morbidity and mortality. There are many large-scale, prospective population studies defining the relationship between plasma total (and Low-density Lipoprotein (LDL)) cholesterol and the future risk of developing CHD. The results of prospective population studies are consistent and support several general conclusions:
The excess non-coronary mortality at low cholesterol levels in the Honolulu Heart Study (Yano et al. 1983; Stemmermann et al. 1991) was apparent only in people who smoked and is consistent with a view that smokers may have occult smoking related disease that is responsible for both an increased mortality and a low plasma cholesterol. It should be emphasised that the prospective studies demonstrate an association between plasma total cholesterol and LDL-C and the risk of developing CHD. (Lipid Management Guidelines - 2001, MJA 2001; 175: S57-S88 and Commonwealth Department of Health & Ageing and Australian Institute of Health and Welfare (1999) National Health Priority Areas Report: Cardiovascular Health 1998. AIHW Cat. No. PHE 9. HEALTH and AIHW, Canberra pgs 14-17). In settings such as general practice where the monitoring of a person's health is ongoing and where a measure can change over time, the service contact date should be recorded. Cardiovascular disease (clinical) NBPDS Health, Superseded 17/10/2018 DSS specific information: Many studies have demonstrated the significance of blood cholesterol components as risk factors for heart, stroke and vascular disease. Scientific studies have shown a continuous relationship between lipid levels and Coronary Heart Disease (CHD) and overwhelming evidence that lipid lowering interventions reduces CHD progression, morbidity and mortality. There are many large-scale, prospective population studies defining the relationship between plasma total (and Low-density Lipoprotein (LDL)) cholesterol and the future risk of developing CHD. The results of prospective population studies are consistent and support several general conclusions:
The excess non-coronary mortality at low cholesterol levels in the Honolulu Heart Study (Yano et al. 1983; Stemmermann et al. 1991) was apparent only in people who smoked and is consistent with a view that smokers may have occult smoking related disease that is responsible for both an increased mortality and a low plasma cholesterol. It should be emphasised that the prospective studies demonstrate an association between plasma total cholesterol and LDL-C and the risk of developing CHD. (Lipid Management Guidelines - 2001, MJA 2001; 175: S57-S88 and Commonwealth Department of Health & Ageing and Australian Institute of Health and Welfare (1999) National Health Priority Areas Report: Cardiovascular Health 1998. AIHW Cat. No. PHE 9. HEALTH and AIHW, Canberra pgs 14-17). In settings such as general practice where the monitoring of a person's health is ongoing and where a measure can change over time, the service contact date should be recorded. Cardiovascular disease (clinical) NBPDS Health, Standard 17/10/2018 DSS specific information: Many studies have demonstrated the significance of blood cholesterol components as risk factors for heart, stroke and vascular disease. Scientific studies have shown a continuous relationship between lipid levels and Coronary Heart Disease (CHD) and overwhelming evidence that lipid lowering interventions reduces CHD progression, morbidity and mortality. There are many large-scale, prospective population studies defining the relationship between plasma total (and Low-density Lipoprotein (LDL)) cholesterol and the future risk of developing CHD. The results of prospective population studies are consistent and support several general conclusions:
The excess non-coronary mortality at low cholesterol levels in the Honolulu Heart Study (Yano et al. 1983; Stemmermann et al. 1991) was apparent only in people who smoked and is consistent with a view that smokers may have occult smoking related disease that is responsible for both an increased mortality and a low plasma cholesterol. It should be emphasised that the prospective studies demonstrate an association between plasma total cholesterol and LDL-C and the risk of developing CHD. (Lipid Management Guidelines - 2001, MJA 2001; 175: S57-S88 and Commonwealth Department of Health & Ageing and Australian Institute of Health and Welfare (1999) National Health Priority Areas Report: Cardiovascular Health 1998. AIHW Cat. No. PHE 9. HEALTH and AIHW, Canberra pgs 14-17). In settings such as general practice where the monitoring of a person's health is ongoing and where a measure can change over time, the service contact date should be recorded. |