Person—low-density lipoprotein cholesterol level (calculated), total millimoles per litre N[N].N
Identifying and definitional attributes
|Metadata item type:||Data Element|
|Short name:||Cholesterol—LDL (calculated)|
|Definition:||A person's calculated low-density lipoprotein cholesterol (LDL-C).|
|Data Element Concept:||Person—low-density lipoprotein cholesterol level|
Value domain attributes
|Maximum character length:||3|
|Unit of measure:||Millimole per litre (mmol/L)|
Data element attributes
Collection and usage attributes
|Guide for use:|
LDL-C = (plasma total cholesterol) - (high density lipoprotein cholesterol) - (fasting plasma triglyceride divided by 2.2).
The LDL-C is usually calculated from the Friedwald Equation (Friedwald et al. 1972), which depends on knowing the blood levels of the total cholesterol and HDL-C and the fasting level of the triglyceride.
Note that the Friedwald equation becomes unreliable when the plasma triglyceride exceeds 4.5 mmol/L.
Note also that while cholesterol levels are reliable for the first 24 hours after the onset of acute coronary syndromes, they may be unreliable for the subsequent 6 weeks after an event.
High blood cholesterol is a key factor in heart, stroke and vascular disease, especially coronary heart disease (CHD).
Poor nutrition can be a contributing factor to heart, stroke and vascular disease as a population's level of saturated fat intake is the prime determinant of its level of blood cholesterol.
The majority of the cholesterol in plasma is transported as a component of LDL-C. Thus, the evidence linking CHD to plasma total cholesterol and LDL-C is essentially the same.
Source and reference attributes
|Submitting organisation:||Cardiovascular Data Working Group|
|Origin:||National Heart Foundation of Australia and the Cardiac Society of Australia and New Zealand, Lipid Management Guidelines - 2001, MJA 2001; 175: S57-S88.|
|Related metadata references:|
Supersedes Cholesterol-LDL calculated, version 1, Derived DE, NHDD, NHIMG, Superseded 01/03/2005 .pdf (19.7 KB) No registration status
Has been superseded by Person—low-density lipoprotein cholesterol level (calculated), total millimoles per litre N[N].N
Is formed using Person—cholesterol level (measured), total millimoles per litre N[N].N
Is formed using Person—high-density lipoprotein cholesterol level (measured), total millimoles per litre [N].NN
Is formed using Person—triglyceride level (measured), total millimoles per litre N[N].N
|Implementation in Data Set Specifications:|
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